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KMID : 0358419720150070321
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Korean Journal of Obstetrics and Gynecology
1972 Volume.15 No. 7 p.321 ~ p.329
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hanges of the Plasma Insulin and Human Growth Hormone Levels in Pregnancy, Postpartum, Cord and Newborn Infants
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Abstract
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Plasma insulin and human growth hormone levels were measured by means of double antibody system of radio-immunoassay techniques in the first-second, and third trimesters of pregnancy, postpartum, umbilical cord blood and the newborn infants. In pregnancy, the blood samples were obtained from the cubital vein at arbitrary- time, while in postpartum and newborn infants, sampling was done as soon as possible after the deliveries.
The relative changes of insulin ´and growth hormon level in each group were estimated and, the following results were obtained:
1. Some decrease in insulin and growth hormone levels were noted in the third trimester of pregnancy compared with those of the first-second trimester.
2. Although no significant changes occured in plasma insulin level between the third trimester of pregnancy and postpartum, somewhat higher level of insulin and significantly lower level of growth hormone were noted in postpartum.
3. There was some difference in plasma insulin level between the postpartum maternal and cord blood, while the plasma human growth hormone level of the cord was significantly higher than that of the postpartum maternal blood.
4. The plasma growth hormone level of the newborn infants was significantly higher than that of mothers in postpartum and slightly higher than that of the cord blood.
5. Changes of plasma insulin, human growth hormone and glucose levels in each trimester of pregnancy were similar to the changing patterns observed in pregnancy following the protein-glucose loading rather than that observed after´the.loading with glucose only.
6. It seems likely that these responses are the characteristics of pregnancy and changes in insulin and growth hormon secretion are the results of the maternal metabolic accommo-.. dation to the increasing intrauterine fetal demends.
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